5-HT1B Serotonin Receptor

A serotonin receptor subtype found at high levels in the BASAL GANGLIA and the frontal cortex. It plays a role as a terminal autoreceptor that regulates the rate of SEROTONIN release from nerve endings. This serotonin receptor subtype is closely related to and has similar drug binding properties as the 5-HT1D RECEPTOR. It is particularly sensitive to the agonist SUMATRIPTAN and may be involved in mediating the drug's antimigraine effect.

Also Known As:

Receptor, Serotonin, 5-HT1B; 5-HT(1B) Receptor; 5-HT(1Dbeta) Receptor; 5-HT1B Receptor; 5-HT1Dbeta Receptor; 5-Hydroxytryptamine 1B Receptor; 5-Hydroxytryptamine 1B Receptors; Receptor, 5-Hydroxytryptamine 1B; Receptor, Serotonin Type 1Dbeta; Serotonin 1D Beta Receptor; Serotonin 1Dbeta Receptor; Serotonin 1Dbeta Receptors; 1B Receptor, 5-Hydroxytryptamine; 1B Receptors, 5-Hydroxytryptamine; 5 HT1B Receptor; 5 HT1Dbeta Receptor; 5 Hydroxytryptamine 1B Receptor; 5 Hydroxytryptamine 1B Receptors; Receptor, 5 Hydroxytryptamine 1B; Receptor, 5-HT1B; Receptor, 5-HT1Dbeta; Receptor, Serotonin 1B; Receptor, Serotonin 1Dbeta; Receptors, 5-Hydroxytryptamine 1B; Receptors, Serotonin 1Dbeta; Serotonin 1B Receptor

Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Membrane Proteins: 10262
    - Cell Surface Receptors: 2156
      - G-Protein-Coupled Receptors: 4858
        Serotonin Receptors: 1919
        5-HT1 Serotonin Receptors: 87
        5-HT1B Serotonin Receptor: 131
      - Neurotransmitter Receptors: 577
        Serotonin Receptors: 1919
        5-HT1 Serotonin Receptors: 87
        5-HT1B Serotonin Receptor: 131
        Presynaptic Receptors: 46
        Autoreceptors: 285
        5-HT1B Serotonin Receptor: 131
      - Biogenic Amine Receptors: 8
        Serotonin Receptors: 1919
        5-HT1 Serotonin Receptors: 87
        5-HT1B Serotonin Receptor: 131

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